make (a/a big/any/...) difference

Examples:

1. Family court makes a big difference in the lives of children.

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2. Vegetables make a big difference in keeping the brain young.

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3. Should height and age make any difference in deciding who we date?

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4.

The question whether gays should marry doesn't make any difference to me - I'm not
gay and I'm not married.

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5.

I think this project will make some difference in rural areas, but I don't know how much
difference it will make in urban areas.